Immunology and Genetic of Preeclampsia

Immunology and Genetic of Preeclampsia

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Preeclampsia is a disease characterized by hypertension and proteinuria in the third trimester of pregnancy.Preeclampsia is a major cause of maternal mortality, and fetal death, especially in developing countries, but its aetiology remains unclear.Key findings support a causal role of superficial placentation driven by immune mal maladaptation, which then lead to reduced concentrations of angiogenic growth factors and to outdoor round junction box for 3 screw base cameras an increase in placental debris in the maternal circulation resulting in a maternal inflammatory response.Epidemiological research has consistently demonstrated a substantial familial predisposition magic pants stoko to preeclampsia.

Unfortunately, the conquest of the genes explaining such a individual susceptibility has been proved to be a hard task.However, genetics will also inform us about causality of environmental factors, and then serve as a tool to prioritize therapeutic targets for preventive strategies.